Document Type
Article
Publication Date
2002
Publication Title
Physical Review E
Volume
65
Issue
2
Pages
021913
DOI
10.1103/PhysRevE.65.021913
Abstract
An electromechanical analysis based on thin-shell theory is presented to analyze cell shape changes in response to external electric fields. This approach can be extended to include osmotic-pressure changes. Our calculations demonstrate that at large fields, the spherical cell geometry can be significantly modified, and even ellipsoidal forms would be inappropriate to account for the deformation. Values of the surface forces obtained from our calculations are in very good agreement with the 1–10 mN/m range for membrane rupture reported in the literature. The results, in keeping with reports in the literature, demonstrate that the final shape depends on membrane thickness. This has direct implications for tissues in which significant molecular restructuring can occur. It is also shown that, at least for the smaller electric fields, both the cellular surface area and volume change roughly in a quadratic manner with the electric field. Finally, it is shown that the bending moments are generally quite small and can be neglected for a simpler analysis.
Original Publication Citation
Joshi, R. P., Hu, Q., Schoenbach, K. H., & Hjalmarson, H. P. (2002). Theoretical predictions of electromechanical deformation of cells subjected to high voltages for membrane electroporation. Physical Review E, 65(2), 021913. doi:10.1103/PhysRevE.65.021913
Repository Citation
Joshi, R. P.; Hu, Q.; Schoenbach, K. H.; and Hjalmarson, H. P., "Theoretical Predictions of Electromechanical Deformation of Cells Subjected to High Voltages for Membrane Electroporation" (2002). Bioelectrics Publications. 259.
https://digitalcommons.odu.edu/bioelectrics_pubs/259
ORCID
0000-0001-7867-7773 (Schoenbach)
Comments
"Yes, the author or the author's employer may use all or part of the APS published article, including the APS-prepared version (e.g., the PDF from the online journal) without revision or modification, on the author's or employer's website as long as a fee is not charged. If a fee is charged, then APS permission must be sought. In all cases, the appropriate bibliographic citation and notice of the APS copyright must be included."
© American Physical Society