Document Type

Article

Publication Date

2020

Publication Title

Bioelectricity

Volume

2

Issue

4

Pages

382-390

DOI

10.1089/bioe.2020.0024

Abstract

Introduction: A method that utilizes nanosecond bipolar cancellation (BPC) near a quadrupole electrodes to suppress a biological response but cancels the distal BPC at the quadrupole center, i.e., cancellation of cancellation (CANCAN), may allow for a remote focused stimulation at the quadrupole center.

Objectives: The primary object of this study was to outline the requirement of the CANCAN implementation and select an effective quadrupole configuration.

Results: We have studied three quadrupole electrode configurations, a rod quadrupole, a plate quadrupole (Plate-Q), and a resistor quadrupole. The pulse shapes of electric fields include monophasic pulses, cancellation pulses, and additive pulses. The Plate-Q appears the best for CANCAN as it shows the highest percentage of cancellation pulses among all pulse shapes, allowing for the best spatial focus.

Conclusion: For the region of interest characterized in the Plate-Q configuration, the maximum magnitude of bipolar field is twice as that of the unipolar field, which allows for the CANCAN demonstration that involves membrane electropermeabilization.

Comments

© 2020 Mary Ann Liebert, Inc.

Included with the written permission of the publisher.

Original Publication Citation

Xiao, S., Yamada, R., & Zhou, C. (2020). Quadrupoles for remote electrostimulation incorporating bipolar cancellation. Bioelectricity, 2(4), 382-390. https://doi.org/10.1089/bioe.2020.0024

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