Document Type

Article

Publication Date

2020

Publication Title

Scholarly Community Encyclopedia

Pages

1-7

DOI

10.32545/encyclopedia202008.0001.v5

Abstract

Heat shock protein 90 (HSP90) is an important chaperone that assists the late stage folding of several proteins involved in cell survival in response to environmental stressors. The inhibition of HSP90 is followed by a complex modulation of the proteome and the kinome, that has proved beneficial in cancer and various neurodegenerative diseases. Additionally, accumulating literature suggests that HSP90 may be a key target during the development of pulmonary fibrosis and that its inhibition could serve as a new and exciting therapeutic approach. We have summarized the current evidence about HSP90’s role in Idiopathic Pulmonary Fibrosis (IPF), the results from preclinical studies on its inhibition and the intracellular signaling pathways involved, in a recent review article (Review). In this Article entry, we will introduce the main findings discussed in the review and focus on its translation and possible significance in the era of the SARS-CoV-2 pandemic.

Comments

© Text is available under the terms and conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) license.

Original Publication Citation

Biancatelli, R. M. L. C., Solopov, P., & Catravas, J. (2020). HSP90 inhibitors for IPF/COVID-19. Scholarly Community Encyclopedia, 1-7. https://doi.org/10.32545/encyclopedia202008.0001.v5

ORCID

0000-0002-1174-3876 (Colunga Biancatelli), 0000-0002-1705-027X (Solopov), 0000-0002-5098-295X (Catravas)

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