ORCID
0000-0001-6575-9729 (Sanders)
Document Type
Editorial
Publication Date
2025
DOI
10.3389/fcell.2025.1653034
Publication Title
Frontiers in Cell and Developmental Biology
Volume
13
Pages
1653034
Abstract
[Introduction] Organ fibrosis represents a substantial a major contributor to global disease burden, implicated in over 30% of cases leading to disability-associated and fatal conditions. Among these conditions, idiopathic pulmonary fibrosis (IPF) stands as a progressive and frequently fatal interstitial lung disease characterized by aberrant extracellular matrix deposition and parenchymal scarring. The prognosis for IPF patients is poor, with a median survival time of just 3–5 years (Bhattacharya and Ramachandran, 2023; Lederer and Martinez, 2018, Ma et al., 2024, Wei et al., 2024). Current FDA-approved therapeutics, Pirfenidone and Nintedanib, demonstrate capacity to attenuate functional decline in pulmonary fibrosis but remain disease-modifying rather than curative. Consequently, elucidating the underlying cellular and molecular mechanisms while developing more effective treatments constitutes an imperative research priority (Bonella et al., 2023, Podolanczuk et al., 2023, Zhang et al., 2023, Zhou et al., 2024).
Rights
© 2025 Qiu, Tang, Shichino, Kushwaha, Sanders, Russo and Mo.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0). The use, distribution or reproduction in other forums is permitted, provided the original authors and the copyright owners are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Original Publication Citation
Qiu, Y., Tang, X. X., Shichino, S., Kushwaha, P. P., Sanders, Y. Y., Russo, R. C., & Mo, C. (2025). Cellular and molecular mechanisms of lung regeneration, repair, and fibrosis, volume II. Frontiers in Cell and Developmental Biology, 13, Article 1653034. https://doi.org/10.3389/fcell.2025.1653034
Repository Citation
Qiu, Y., Tang, X. X., Shichino, S., Kushwaha, P. P., Sanders, Y. Y., Russo, R. C., & Mo, C. (2025). Cellular and molecular mechanisms of lung regeneration, repair, and fibrosis, volume II. Frontiers in Cell and Developmental Biology, 13, Article 1653034. https://doi.org/10.3389/fcell.2025.1653034