ORCID
0000-0001-6575-9729 (Sanders)
Document Type
Editorial
Publication Date
2025
DOI
10.3389/fmolb.2025.1718307
Publication Title
Fronteris in Molecular Biosciences
Volume
12
Pages
1718307
Abstract
[Introduction] Fibrosis is one of the pathological conditions underlying the progression of numerous chronic diseases, and it contributes substantially to morbidity and mortality worldwide. Increasing amounts of evidence indicate that epigenetic mechanisms—including DNA methylation, histone modifications, RNA modifications, and non-coding RNAs—play pivotal roles in epithelial cell injury and maladaptive tissue repair, inflammatory cell and fibroblast activation, and extracellular matrix remodeling and accumulation. Compared to genetic alterations, epigenetic changes are relatively reversible, positioning them as promising therapeutic targets. The articles collected in this Research Topic highlight recent advances in understanding how epigenetic regulation shapes fibrotic processes across multiple organ systems and provides new opportunities for biomarker discovery and therapeutic intervention.
Rights
© 2025 Wei, Hu and Sanders.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0). The use, distribution or reproduction in other forums is permitted, provided the original authors and the copyright owners are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Original Publication Citation
Wei, Q., Hu, X., & Sanders, Y. (2025). Epigenetic regulation in fibrosis. Frontiers in Molecular Biosciences, 12, Article 1718307. https://doi.org/10.3389/fmolb.2025.1718307
Repository Citation
Wei, Q., Hu, X., & Sanders, Y. (2025). Epigenetic regulation in fibrosis. Frontiers in Molecular Biosciences, 12, Article 1718307. https://doi.org/10.3389/fmolb.2025.1718307