Radiation Induced Skin Fibrosis (RISF): Opportunity for Angiotensin II-Dependent Intervention

Authors

Patricia F. Boothe, Macon & Joan Brock Virginia Health Sciences at Old Dominion University
Vidya P. Kumar, The Uniformed Services University of the Health Sciences
Yali Kong, Macon & Joan Brock Virginia Health Sciences at Old Dominion UniversityFollow
Kan Wang, Macon & Joan Brock Virginia Health Sciences at Old Dominion UniversityFollow
Howard Levinson, The Center for Plastic Surgery at Sentara
David Mu, Macon & Joan Brock Virginia Health Sciences at Old Dominion UniversityFollow
Milton L. Brown, Macon & Joan Brock Virginia Health Sciences at Old Dominion UniversityFollow

ORCID

0000-0002-7762-0182 (Mu), 0009-0009-0489-8245 (Brown)

Document Type

Article

Publication Date

2024

DOI

10.3390/ijms25158261

Publication Title

International Journal of Molecular Sciences

Volume

25

Issue

15

Pages

8261 (1-17)

Abstract

Medical procedures, such as radiation therapy, are a vital element in treating many cancers, significantly contributing to improved survival rates. However, a common long-term complication of such exposure is radiation-induced skin fibrosis (RISF), a complex condition that poses substantial physical and psychological challenges. Notably, about 50% of patients undergoing radiation therapy may achieve long-term remission, resulting in a significant number of survivors managing the aftereffects of their treatment. This article delves into the intricate relationship between RISF, reactive oxygen species (ROS), and angiotensin II (Ang II) signaling. It proposes the underlying mechanisms and examines potential treatments for mitigating skin fibrosis. The primary goal is to offer essential insights in order to better care for and improve the quality of life of cancer survivors who face the risk of developing RISF.

Rights

© 2024 by the Authors.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) License.

Data Availability

Article states: "The datasets and materials used and/or analyzed during the current study are available from the corresponding author upon reasonable request."

Original Publication Citation

Boothe, P. F., Kumar, V. P., Kong, Y., Wang, K., Levinson, H., Mu, D., & Brown, M. L. (2024). Radiation induced skin fibrosis (RISF): Opportunity for angiotensin II-dependent intervention. International Journal of Molecular Sciences, 25(15), 1-17, Article 8261. https://doi.org/10.3390/ijms25158261

Repository Citation

Boothe, P. F., Kumar, V. P., Kong, Y., Wang, K., Levinson, H., Mu, D., & Brown, M. L. (2024). Radiation induced skin fibrosis (RISF): Opportunity for angiotensin II-dependent intervention. International Journal of Molecular Sciences, 25(15), 1-17, Article 8261. https://doi.org/10.3390/ijms25158261