Date of Award
Summer 1997
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Program/Concentration
Cardiovascular Science
Committee Director
Russell L. Prewitt
Committee Member
Stephen J. Beebe
Committee Member
Mark S. Elliot
Committee Member
Thomas J. Lauterio
Committee Member
Paul H. Ratz
Abstract
This study was designed to characterize structural remodeling of male Wistar rat mesenteric arteries exposed to elevated blood flow in vivo for 1, 3, or 7 days. A series of arterial ligations induced blood flow increases in ileal and second-order branch arteries compared to same animal control vessels. Neither mean carotid nor local mesenteric arterial pressures changed significantly pre- to post-ligation. The primary flow-mediated force in both vessels was shear stress with possible involvement of acute stretch-induced wall stress in the ileal artery. Significant luminal expansion and medial wall hypertrophy occurred in the ileal and second-order arteries in a time-dependent fashion. Increases in extracellular connective tissue occurred concomitantly with arterial remodeling. Wall thickness to lumen diameter ratios did not change in any vessel at any time when compared to controls, suggesting normalization of flow-induced wall stress through vascular remodeling.
DOI
10.25777/3mza-eb82
ISBN
9780591603989
Recommended Citation
Tulis, David A..
"Endothelial Nitric Oxide Synthase and Growth Factor Regulation of Flow-Mediated Vascular Remodeling"
(1997). Doctor of Philosophy (PhD), Dissertation, , Old Dominion University, DOI: 10.25777/3mza-eb82
https://digitalcommons.odu.edu/biomedicalsciences_etds/87
Included in
Animal Structures Commons, Biophysics Commons, Cardiovascular System Commons, Physiology Commons, Surgery Commons
Comments
A Dissertation Submitted to the Faculty of Old Dominion University and Eastern Virginia Medical School in Partial Fulfillment of the Requirement for the Degree of Doctor of Philosophy in Biomedical Sciences.