Synthesis and Characterization of Cobalt(III) Complexes and a Vanadium(IV) Complex with Flavonoids as Ligands

Author

Ethan Schroeder, Old Dominion UniversityFollow

Date of Award

Summer 8-2023

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry and Biochemistry

Program/Concentration

Chemistry

Committee Director

Alvin A. Holder

Committee Member

Kyle Lambert

Committee Member

Trandon Bender

Committee Member

Xiaoyu Zhang

Abstract

For many years now, transition metal complexes have been used as favorable additional chemotherapeutic approaches to medicine that were previously unexplored in the literature. One well-known chemotherapeutic drug, cisplatin, has been applied, but is limited in use due to its toxicity to the cells and its undesirable side effects to humans. Newly developed cobalt-based complexes with ligands known as flavonoids are being used to fight cancer. Flavonoids, compounds mainly found in fruits and vegetables, are shown to have antioxidative and anticancer properties. Use of flavonoids as ligands in transition metal complexes, e.g., those with a Ru(II) metal center, have been proven to have increased anti-cancer properties as reported in the literature. Attempted syntheses of three cobalt(III) complexes with flavonoid as ligands, viz., baicalein, chrysin, and quercetin, were carried out, but based on physical characterizations with ¹H NMR, ¹³C NMR, and cyclic voltammetry studies the product was found to be [Co(phen)₃](PF₆)₃. A vanadium(IV) complex was also synthesized and characterized, but with quercetin as a ligand. Characterization of the complexes were carried out using elemental analysis, conductivity measurements, FTIR, ¹H and ¹³C NMR, and UV-visible spectroscopies, and electrochemistry via cyclic voltammetry, where appropriate.

Rights

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DOI

10.25777/m1hs-c087

ISBN

9798380394390

Recommended Citation

Schroeder, Ethan. "Synthesis and Characterization of Cobalt(III) Complexes and a Vanadium(IV) Complex with Flavonoids as Ligands" (2023). Master of Science (MS), Thesis, Chemistry and Biochemistry, Old Dominion University, DOI: 10.25777/m1hs-c087
https://digitalcommons.odu.edu/chemistry_etds/72

ORCID

0009-0004-4677-966X