Document Type

Letter to the Editor

Publication Date

2007

DOI

10.1038/sj.cgt.7701043

Publication Title

Cancer Gene Therapy

Volume

14

Issue

5

Pages

519-520

Abstract

Neoplastic growths represent a unique challenge for the host immune system. As they are indeed derived from self, many of the same mechanisms operating to prevent autoimmunity also provide an umbrella beneath which malignant cells are free to proliferate.1 Central among these immune regulatory boundaries are an influential subset of lymphocytes known as T regs. Hypothesized to exist decades ago, yet eluding definitive characterization until relatively recently, T regs have been demonstrated to play a crucial role in the proper functioning of the immune system as a whole. They may also, however, represent one of the primary obstacles to successful anti-tumor immunotherapies.

Comments

Web of Science: "Free full-text from publisher."

Original Publication Citation

Klaiber, N. (2007). Potential for stimulating host anti-tumor immune response via RNAi-mediated local FOXP3 knockdown. Cancer Gene Therapy, 14(5), 519-520. doi:10.1038/sj.cgt.7701043

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