Document Type
Article
Publication Date
2012
DOI
10.1016/j.febslet.2012.02.040
Publication Title
FEBS Letters
Volume
586
Issue
7
Pages
962-966
Abstract
The protein folding process has been studied both computationally and experimentally for over 30 years. To date there is no detailed mechanism to explain the formation of long-range interactions between the transition and native states. Long-range interactions are the principle determinants of the tertiary structure. We present a theoretical model which proposes a mechanism for the acquisition of these interactions as they form in a modified version of ‘degrees of separation’, that we term ‘levels of separation’. It is based on the integration of network science and biochemistry. (C) 2012 Federation of European Biochemical Societies.
Original Publication Citation
Greene, L. H., & Grant, T. M. (2012). Protein folding by 'levels of separation': A hypothesis. FEBS Letters, 586(7), 962-966. doi:10.1016/j.febslet.2012.02.040
Repository Citation
Greene, Lesley H. and Grant, Terri M., "Protein Folding by 'Levels of Separation': A Hypothesis" (2012). Chemistry & Biochemistry Faculty Publications. 135.
https://digitalcommons.odu.edu/chemistry_fac_pubs/135
Included in
Biochemistry Commons, Biophysics Commons, Cell Biology Commons, Molecular Biology Commons
Comments
Web of Science: "Free full-text from publisher."