Document Type

Article

Publication Date

2023

DOI

10.1016/j.mitoco.2023.09.001

Publication Title

Mitochondrial Communications

Volume

1

Pages

62-72

Abstract

The transmembrane-electrostatically localized protons (TELP) theory may represent a complementary development to Mitchell's chemiosmotic theory. The combination of the two together can now excellently explain the energetics in mitochondria. Our calculated transmembrane-attractive force between an excess proton and an excess hydroxide explains how TELP may stay within a 1-nm thin layer at the liquid-membrane interface. Consequently, any pH sensor (sEcGFP) located at least 2–3 nm away from the membrane surface will not be able to see TELP. This feature as predicted from the TELP model was observed exactly in the experiment of Rieger et al., 2021. In contrast to their belief “the Δp at ATP synthase is almost negligible under OXPHOS conditions”, I find, when TELP activity is included in the energy calculations, there is plenty of total protonic Gibbs free energy (ΔGT) well above the physiologically required value of −24.5 kJ mol−1 to drive ATP synthesis through F0F1-ATP synthase.

Rights

© 2023 The Authors.

This is an open access article under the Creative Commons Attribution 4.0 International (CC BY 4.0) License.

Data Availability

Article states: "All data generated or analyzed during the study are included in this article and in the cited references."

Original Publication Citation

Lee, J. W. (2023). TELP theory: Elucidating the major observations of Rieger et al. 2021 in mitochondria. Mitochondrial Communications, 1, 62-72. https://doi.org/10.1016/j.mitoco.2023.09.001

ORCID

0000-0003-2525-5870 (Lee)

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