Document Type
Response or Comment
Publication Date
2023
DOI
10.1128/jb.00188-23
Publication Title
Journal of Bacteriology
Volume
205
Issue
10
Pages
e0018823 (1-7)
Abstract
The intestinal pathogen Clostridioides difficile encodes roughly 50 TCS, but very few have been characterized in terms of their activating signals or their regulatory roles. A. G. Pannullo, B. R. Zbylicki, and C. D. Ellermeier (J Bacteriol 205:e00164-23, 2023, https://doi.org/10.1128/jb.00164-23) have identified both for the novel C. difficile TCD DraRS. DraRS responds to antibiotics that target lipid-II molecules in the bacterial cell envelope, and regulates the production of a novel glycolipid necessary for bacitracin and daptomycin resistance in C. difficile.
Rights
© 2023 Berumen Alvarez and Purcell.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Original Publication Citation
Berumen Alvarez, O., & Purcell, E. B. (2023). Expanding our grasp of two-component signaling in Clostridioides difficile. Journal of Bacteriology, 205(10), 1-7, Article e0018823. https://doi.org/10.1128/jb.00188-23
Repository Citation
Alvarez, Orlando Berumen and Purcell, Erin B., "Expanding Our Grasp of Two-Component Signaling in Clostridioides difficile" (2023). Chemistry & Biochemistry Faculty Publications. 283.
https://digitalcommons.odu.edu/chemistry_fac_pubs/283
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