Response or Comment
Journal of Bacteriology
The intestinal pathogen Clostridioides difficile encodes roughly 50 TCS, but very few have been characterized in terms of their activating signals or their regulatory roles. A. G. Pannullo, B. R. Zbylicki, and C. D. Ellermeier (J Bacteriol 205:e00164-23, 2023, https://doi.org/10.1128/jb.00164-23) have identified both for the novel C. difficile TCD DraRS. DraRS responds to antibiotics that target lipid-II molecules in the bacterial cell envelope, and regulates the production of a novel glycolipid necessary for bacitracin and daptomycin resistance in C. difficile.
© 2023 Berumen Alvarez and Purcell.
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Original Publication Citation
Berumen Alvarez, O., & Purcell, E. B. (2023). Expanding our grasp of two-component signaling in Clostridioides difficile. Journal of Bacteriology, 205(10), 1-7, Article e0018823. https://doi.org/10.1128/jb.00188-23
Alvarez, Orlando Berumen and Purcell, Erin B., "Expanding Our Grasp of Two-Component Signaling in Clostridioides difficile" (2023). Chemistry & Biochemistry Faculty Publications. 283.