Document Type

Article

Publication Date

2024

DOI

10.1039/D4OB00636D

Publication Title

Organic and Biomolecular Chemistry

Volume

22

Issue

27

Pages

5470-5510

Abstract

Carbohydrate-based self-assembling systems are essential for the formation of advanced biocompatible materials via a bottom-up approach. The self-assembling of sugar-based small molecules has applications encompassing many research fields and has been studied extensively. In this focused review, we will discuss the synthetic approaches for carbohydrate-based self-assembling (SA) systems, the mechanisms of the assembly, as well as the main properties and applications. This review will mainly cover recent publications in the last four years from January 2020 to December 2023. We will essentially focus on small molecule self-assembly, excluding polymer-based systems, which include various derivatives of monosaccharides, disaccharides, and oligosaccharides. Glycolipids, glycopeptides, and some glycoconjugate-based systems are discussed. Typically, in each category of systems, the system that can function as low molecular weight gelators (LMWGs) will be discussed first, followed by self-assembling systems that produce micelles and aggregates. The last section of the review discusses stimulus-responsive self-assembling systems, especially those forming gels, including dynamic covalent assemblies, chemical-triggered systems, and photoresponsive systems. The review will be organized based on the sugar structures, and in each category, the synthesis of representative molecular systems will be discussed next, followed by the properties of the resulting molecular assemblies.

Rights

© 2024 The Royal Society of Chemistry.

This article is licensed under a Creative Commons Attribution 3.0 Unported License (CC BY 3.0).

Original Publication Citation

Wang, G., Chen, A., Aryal, P., & Bietsch, J. (2024). Synthetic approaches of carbohydrate based self-assembling systems. Organic and Biomolecular Chemistry, 22(27), 5470-5510. https://doi.org/10.1039/d4ob00636d

ORCID

0000-0001-7473-0004 (Wang), 0000-0002-8943-9663 (Chen), 0009-0007-8137-1370 (Aryal),

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