Document Type

Article

Publication Date

2025

DOI

10.15416/pcpr.v10i2.59067

Publication Title

Pharmacology and Clinical Pharmacy Research

Volume

10

Issue

2

Pages

127-137

Abstract

Vernonia amygdalina, a traditionally used medicinal plant, has been purported to possess health-promoting properties. The aim of this study is to investigate the phytochemical and nutritional composition of V. amygdalina, evaluate its antioxidant and antidiabetic efficacy, and assess its hematological benefits. Phytochemical screening, proximate analysis, antioxidant assays (DPPH, ABTS), antidiabetic evaluations in treptozotocin induced diabetic rats, and hematological assessments were conducted according to standard protocol. V. amygdalina exhibited a rich phytochemical profile, comprising flavonoids, phenolic acids, and terpenoids, alongside significant antioxidant activity (IC50 = 12.5 μg/mL) and complete source of protein. Proximate analysis revealed high protein (21.1%) and fiber (15.6%) content. Antidiabetic evaluations demonstrated significant reductions in blood glucose levels (p < 0.01). Hematological assessments showed significant improvements in hemoglobin (14.1 ± 0.6 g/dL), packed cell volume (42.9 ± 1.8%), red blood cell count (7.1 ± 0.3 x 10^12/L), and differential WBC count, including reduced monocyte (6.3 ± 0.9%) and eosinophil (2.6 ± 0.6%) percentages, and increased lymphocyte (34.4 ± 2.4%) percentage. This study provides comprehensive evidence for the phytochemical, nutritional, and pharmacological value of V. amygdalina, underscoring its potential as a functional food and phytomedicine for oxidative stress and diabetes management, as well as a natural adjunct for improving hematological parameters.

Rights

© 2024 The Authors.

This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-SA 4.0) License.

Comments

As of August 2025, the DOI to this article, https://doi.org/10.15416/pcpr.v10i2.59067, is non-functional.

Original Publication Citation

Adewuyi, H. A., Atapia, M., Ochonung, E., Waheed, S. A., Oluwatoyin, A. H., Obunadike, C. V., Edema, A. A., Hussein, S., Mohammed, U. A., Sebastine, K. L., & Jaiyeola, T. O. (2025). Phytochemical and nutritional composition of Vernonia amygdalina: Antioxidant, antidiabetic efficacy, and hematological benefits. Pharmacology and Clinical Pharmacy Research, 10(2), 127-137. https://doi.org/10.15416/pcpr.v10i2.59067

ORCID

0000-0002-4546-0153 (Waheed)

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