Document Type

Article

Publication Date

2025

DOI

10.32598/PBR.11.2.1365.1

Publication Title

Pharmaceutical & Biomedical Research

Volume

11

Issue

2

Pages

139-146

Abstract

Background: Hypertension is a major public health concern worldwide, contributing to cardiovascular morbidity and mortality. The use of plant-based therapies, such as Euphorbia hirta and Leptadenia hastata, has gained attention for their potential antioxidant, anti-hyperlipidemic, and organ-protective effects.

Objectives: This study aimed to investigate the phytotherapeutic approach to hypertension using E. hirta and L. hastata extracts in adrenaline-induced hypertensive Wistar rats

Methods: Utilizing an adrenaline-induced hypertensive rat model, we assessed the effects of E. hirta and L. hastata leaf extracts (50, 100, and 200 mg/kg) on systolic blood pressure, renal function, lipid metabolism, and hematological parameters.

Results: Antioxidant activity: Increased levels of superoxide dismutase, catalase, and glutathione peroxidase. Lipid profiles: Reduced levels of total cholesterol, triglycerides, and LDL cholesterol. Liver function tests (LFTs): Decreased levels of alanine transaminase and aspartate transaminase. Hematological parameters: Improved red blood cell count, hemoglobin, and packed cell volume (PCV).

Conclusion: This preclinical investigation provides compelling evidence for the antihypertensive potential of E. hirta and L. hastata leaf extracts, validating their traditional use. These findings underscore the promise of these natural products as adjunctive therapeutics for hypertension management, warranting further clinical investigation.

Rights

© 2025 The Authors.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC-BY-NC 4.0), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and it is not used for commercial purposes.

Original Publication Citation

Bushirat, F. O., Ochonung, E. O., Atapia, M. I., Adewuyi, H. A., Waheed, S. A., Hameedah, A. O., Obunadike, C. V., Edema, A. A., Hussein, S., Usman, A. M., & Jaiyeola, T. O. (2025). Antihypertensive potential of Euphorbia hirta and Leptadenia hastata in adrenaline-induced Wistar rats. Pharmaceutical & Biomedical Research, 11(2), 139-146. https://doi.org/10.32598/PBR.11.2.1365.1

ORCID

0000-0002-4546-0153 (Waheed)

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