Date of Award

Fall 2009

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Dental Hygiene

Program/Concentration

Dental Hygiene

Committee Director

Michele L. Darby

Committee Member

Lynn Tolle

Committee Member

Mounir Laroussi

Committee Member

Wayne Hynes

Call Number for Print

Special Collections LD4331.D46 M35 2009

Abstract

Purpose: The biomedical application of low temperature atmospheric pressure plasma (LTAPP) is a collaborative interest for engineering, medical, dental and biological researchers. This laboratory study tested whether LTAPP can limit growth of Porphyromonas gingivalis, a periodontal pathogen strongly associated with periodontal disease, disease progression, and refractory periodontitis. Methods: After extensive pilot trials, the study consisted of 24 agar plate samples of P. gingivalis- 20 samples were exposed to LTAPP at 5, 7, 9 and 10 minutes and 4 control samples were exposed to helium gas only. Immediately after exposures, the samples were incubated anaerobically for 72 hour at 3 7°C. After 72 hours, zones of inhibition were measured. Results: After 5, 7, 9, and 11 minutes of exposure times, results reveal a statistically significant difference in the bactericidal effect of the LTAPP on P. gingivalis compared to control bacteria not exposed, as measured by zone of inhibition (cm) (pConclusions: LTAPP has a significant dose related bactericidal effect on P. gingivalis, as measured by zone of inhibition.

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DOI

10.25777/6p2x-7q33

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