Journal of Diabetes Research
1467213 (11 pages)
Objective. Examine the effectiveness of the 128 Hz tuning fork, two monofilaments, and Norfolk Quality of Life Diabetic Neuropathy (QOL-DN) questionnaire as tools for the early detection of diabetic peripheral neuropathy (DPN) in overweight, obese, and inactive (OOI) adults or those who have prediabetes (PD) or type 2 diabetes (T2D). Research Design and Methods. Thirty-four adults (mean age 58.4 years +/- 12.1) were divided by glycemia (10 OOI normoglycemic, 13 PD, and 11 T2D). Sural nerves were tested bilaterally with the NC-stat DPNCheck to determine sural nerve amplitude potential (SNAP) and sural nerve conduction velocity (SNCV). All other testing results were compared to SNAP and SNCV. Results. Total 1 g monofilament scores significantly correlated with SNAP values and yielded the highest sensitivity and specificity combinations of tested measures. Total QOL-DN scores negatively correlated with SNAP values, as did QOL-DN symptoms. QOL-DN activities of daily living correlated with the right SNAP, and the QOL-DN small fiber subscore correlated with SNCV. Conclusions. The 1 g monofilament and total QOL-DN are effective, low-cost tools for the early detection of DPN in OOI, PD, and T2D adults. The 128 Hz tuning fork and 10 g monofilament may assist DPN screening as a tandem, but not primary, early DPN detection screening tools.
0000-0001-9157-3493 (Pribesh), 0000-0001-7574-2533 (Colberg)
Original Publication Citation
Brown, J. J., Pribesh, S. L., Baskette, K. G., Vinik, A. I., & Colberg, S. R. (2017). A comparison of screening tools for the early detection of peripheral neuropathy in adults with and without type 2 diabetes. Journal of Diabetes Research, 2017, 1467213. doi:10.1155/2017/1467213
Brown, Jennifer J.; Pribesh, Shana; Baskette, Kimberly G.; Vinik, Aaron I.; and Colberg, Sheri R., "A Comparison of Screening Tools for the Early Detection of Peripheral Neuropathy in Adults With and Without Type 2 Diabetes" (2017). Educational Foundations & Leadership Faculty Publications. 21.