ORCID

0000-0002-8163-0527 (Carbone)

Document Type

Article

Publication Date

2025

DOI

10.1002/jpen.70013

Publication Title

Journal of Parenteral and Enteral Nutrition

Volume

49

Issue

8

Pages

1002-1011

Abstract

Background

Appendicular lean mass index is a major determinant of cardiorespiratory fitness in patients with obesity-related heart failure with preserved ejection fraction (HFpEF). Moreover, appendicular lean mass index can be used to diagnose sarcopenia and sarcopenic obesity in this population. We aimed to validate the ability of segmental single-frequency bioelectrical impedance analysis (SF-BIA) to assess body composition compared with dual-energy x-ray absorptiometry (DXA) in patients with HFpEF and obesity, with a focus on appendicular lean mass index for its critical role in diagnosing sarcopenia and sarcopenic obesity.

Methods

We analyzed 62 euvolemic patients from a heart failure outpatient clinic with persistent obesity-related HFpEF (83.8% women, 60.8 ± 2.8 years of age). We used DXA and segmental SF-BIA.

Results

Strong correlations were found between segmental SF-BIA and DXA for appendicular lean mass index (r = 0.897), appendicular fat mass index (r = 0.864), fat mass (r = 0.968), fat mass percentage (r = 0.867), fat-free mass (r = 0.954), fat-free mass percentage (r = 0.852), fat mass index (r = 0.97), and fat-free mass index (r = 0.88) (all p <  0.001), without significant proportional bias for all parameters, except for appendicular fat mass index.

Conclusions

Segmental SF-BIA-measured body composition shows strong correlations, appropriate agreements, and no proportional bias compared with DXA. Segmental SF-BIA should be considered in patients with obesity-related HFpEF.

Rights

© 2025 The Authors.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Original Publication Citation

Salmons, H., Ahmed, S. I., Billingsley, H. E., Reavey-Cantwell, A., Markley, R., Golino, M., Del Buono, M. G., Damonte, J. I., Pinel, S., Franco, R. L., Abbate, A., Earthman, C. P., & Carbone, S. (2025). Body composition in patients with obesity-related heart failure with preserved ejection fraction: A comparison study. Journal of Parenteral and Enteral Nutrition, 49(8), 1002-1011. https://doi.org/10.1002/jpen.70013

Additional Files
jpen70013-sup-0001-supplemental_table_1_january_3_2025.docx (16 kB)
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