Document Type

Article

Publication Date

2021

DOI

10.1111/php.13467

Publication Title

Photochemistry and Photobiology

Volume

98

Issue

1

Pages

17-41

Abstract

Photodynamic therapy (PDT) is a medicinal tool that uses a photosensitiser and a light source to treat several conditions, including cancer. PDT uses reactive oxygen species (ROS) such as cytotoxic singlet oxygen 1O2 to induce cell death in cancer cells. Chemotherapy has historically utilized the cytotoxic effects of many metals, especially transition-metal complexes. However, chemotherapy is a systemic treatment so all cells in a patient's body are exposed to the same cytotoxic effects. Transition metal complexes have also shown high cytotoxicity as PDT agents. PDT is a potential localized method for treating several cancer types by using inorganic complexes as photosensitizing agents. This review covers several in vitro and in vivo studies, as well as clinical trials that reported on the anti-cancer properties of inorganic pharmaceuticals used in PDT against different types of cancer.

Comments

© 2021 American Society for Photobiology

This is the peer reviewed version of the following article:

Smith, C. B., Days, L. C., Alajroush, D. R., Faye, K., Khodour, Y., Beebe, S. J., & Holder, A. A. (2021, Jun 14). Photodynamic therapy of inorganic complexes for the treatment of cancer. Photochemistry and Photobiology, Article in Press, 1-84.

Version of record can be accessed here: https://doi.org/10.1111/php.13467. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Original Publication Citation

Smith, C. B., Days, L. C., Alajroush, D. R., Faye, K., Khodour, Y., Beebe, S. J., & Holder, A. A. (2021). Photodynamic therapy of inorganic complexes for the treatment of cancer. Photochemistry and Photobiology, Article in Press, 1-84. https://doi.org/10.1111/php.13467

ORCID

0000-0002-6075-9452 (Beebe), 0000-0001-9618-5297 (Holder)

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