Document Type

Article

Publication Date

2021

DOI

10.3390/chemistry3030068

Publication Title

Chemistry

Volume

3

Issue

3

Pages

935-958

Abstract

Carbohydrate-based low-molecular-weight gelators (LMWGs) are useful classes of compounds due to their numerous applications. Among sugar-based LMWGs, certain peracetylated sugar beta-triazole derivatives were found to be effective organogelators and showed interesting self-assembling properties. To further understand the structural influence towards molecular assemblies and obtain new functional materials with interesting properties, we designed and synthesized a library of tetraacetyl beta-1-triazolyl alkyl-D-glucosides and D-galactosides, in which a two or three carbon spacer is inserted between the anomeric position and the triazole moiety. A series of 16 glucose derivatives and 14 galactose derivatives were synthesized and analyzed. The self-assembling properties of these new triazole containing glycoconjugates in different solvents were analyzed. Several glucose derivatives were found to be effective LMWGs, with compound 7a forming gels in a variety of organic solvents as well as in the presence of metal ions in aqueous solutions. The organogels formed by several compounds were characterized using optical microscopy, atomic force microscopy (AFM) and UV-vis spectroscopy, etc. The co-gels formed by compound 7a with the Fmoc derivative 7i showed interesting fluorescence enhancement upon gelation. Several gelators were also characterized using powder X-ray diffraction and FT-IR spectroscopy. The potential applications of these sugar-based gelators for drug delivery and dye removal were also studied.

Comments

© 2021 by the authors.

This is an open access article distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Original Publication Citation

Sharma, P., Chen, A., Wang, D., & Wang, G. (2021). Synthesis and self-assembling properties of peracetylated β-1-triazolyl alkyl D-glucosides and D-galactosides. Chemistry, 3(3), 935-958. https://doi.org/10.3390/chemistry3030068

ORCID

0000-0003-4132-1196 (Sharma), 0000-0002-8943-9663 (Chen), 0000-0001-7473-0004 (Wang)

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