Document Type

Article

Publication Date

2014

DOI

10.1016/j.bbamem.2013.11.003

Publication Title

Biochimica et Biophysica Acta: Biomembranes

Volume

1838

Issue

3

Pages

902-909

Abstract

The dynamical translocation of lipids from one leaflet to another due to membrane permeabilization driven by nanosecond, high-intensity (>100 kV/cm) electrical pulses has been probed. Our simulations show that lipid molecules can translocate by diffusion through water-filled nanopores which form following high voltage application. Our focus is on multiple pulsing, and such simulations are relevant to gauge the time duration over which nanopores might remain open, and facilitate continued lipid translocations and membrane transport. Our results are indicative of a N1/2 scaling with pulse number for the pore radius. These results bode well for the use of pulse trains in biomedical applications, not only due to cumulative behaviors and in reducing electric intensities and pulsing hardware, but also due to the possibility of long-lived thermo-electric physics near the membrane, and the possibility for pore coalescence. © 2013 Elsevier B.V. All rights reserved.

Comments

Web of Science: "Free full-text from publisher -- gold open access."

Original Publication Citation

Sridhara, V., & Joshi, R. P. (2014). Numerical study of lipid translocation driven by nanoporation due to multiple high-intensity, ultrashort electrical pulses. Biochimica et Biophysica Acta: Biomembranes, 1838(3), 902-909. doi:10.1016/j.bbamem.2013.11.003

Download

Share

COinS