Document Type

Article

Publication Date

2014

DOI

10.1016/j.bbamem.2014.03.010

Publication Title

Biochimica Et Biophysica Acta: Biomembranes

Volume

1838

Issue

7

Pages

1793-1800

Abstract

The effect of ions present in the extracellular medium on electroporation by high-intensity, short-duration pulsing is studied through molecular dynamic simulations. Our simulation results indicate that mobile ions in the medium might play a role in creating stronger local electric fields across membranes that then reinforce and strengthen electroporation. Much faster pore formation is predicted in higher conductivity media. However, the impact of extracellular conductivity on cellular inflows, which depend on transport processes such as electrophoresis, could be different as discussed here. Our simulation results also show that interactions between cations (Na+ in this case) and the carbonyl oxygen of the lipid headgroups could impede pore resealing.

Comments

Elsevier open archive.

© 2014 Elsevier B.V. All rights reserved.

Original Publication Citation

Sridhara, V., & Joshi, R. P. (2014). Evaluations of a mechanistic hypothesis for the influence of extracellular ions on electroporation due to high-intensity, nanosecond pulsing. Biochimica Et Biophysica Acta: Biomembranes, 1838(7), 1793-1800. doi:10.1016/j.bbamem.2014.03.010

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