Document Type
Article
Publication Date
2014
DOI
10.1016/j.bbamem.2014.03.010
Publication Title
Biochimica Et Biophysica Acta: Biomembranes
Volume
1838
Issue
7
Pages
1793-1800
Abstract
The effect of ions present in the extracellular medium on electroporation by high-intensity, short-duration pulsing is studied through molecular dynamic simulations. Our simulation results indicate that mobile ions in the medium might play a role in creating stronger local electric fields across membranes that then reinforce and strengthen electroporation. Much faster pore formation is predicted in higher conductivity media. However, the impact of extracellular conductivity on cellular inflows, which depend on transport processes such as electrophoresis, could be different as discussed here. Our simulation results also show that interactions between cations (Na+ in this case) and the carbonyl oxygen of the lipid headgroups could impede pore resealing.
Original Publication Citation
Sridhara, V., & Joshi, R. P. (2014). Evaluations of a mechanistic hypothesis for the influence of extracellular ions on electroporation due to high-intensity, nanosecond pulsing. Biochimica Et Biophysica Acta: Biomembranes, 1838(7), 1793-1800. doi:10.1016/j.bbamem.2014.03.010
Repository Citation
Sridhara, V. and Joshi, R. P., "Evaluations of a Mechanistic Hypothesis for the Influence of Extracellular Ions on Electroporation Due to High-Intensity, Nanosecond Pulsing" (2014). Electrical & Computer Engineering Faculty Publications. 167.
https://digitalcommons.odu.edu/ece_fac_pubs/167
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