Document Type

Article

Publication Date

2023

DOI

10.3389/fendo.2023.1085958

Publication Title

Frontiers in Endocrinology

Volume

14

Pages

1085958 (1-9)

Abstract

Polychlorinated biphenyls (PCBs) are persistent environmental organic pollutants known to have detrimental health effects. Using a mouse model, we previously demonstrated that PCB126 exposure before and during pregnancy and throughout the perinatal period adversely affected offspring glucose tolerance and/or body composition profiles. The purpose of this study was to investigate the glucose tolerance and body composition of offspring born to dams exposed to PCB126 during the nursing period only. Female ICR mice were bred, and half of the dams were exposed to either vehicle (safflower oil) or 1 µmole PCB126 per kg of body weight via oral gavage on postnatal days (PND) 3, 10, and 17 (n = 9 per group). Offspring body weight, lean and fat mass, and glucose tolerance were recorded every three weeks. PCB126 treatment did not alter dam nor offspring body weight (p > 0.05). PCB126-exposed male and female offspring displayed normal body composition (p > 0.05) relative to vehicle-exposed offspring. However, both male and female offspring that were exposed to PCB126 during the nursing period had significantly impaired glucose tolerance at 3 and 9 weeks of age (p < 0.05). At 6 and 12 weeks of age, no impairments in glucose tolerance existed in offspring (p > 0.05). Our current study demonstrates that exposure to PCB126 through the mother's milk does not affect short- or long-term body composition but impairs glucose tolerance in the short-term.

Rights

© 2023 Rice, Sammons, Ngo Tenlep, Weltzer, Reynolds, Rashid, Swanson and Pearson.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Data Availability

Article states: The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

Original Publication Citation

Rice, B. B., Sammons, K. W., Ngo Tenlep, S. Y., Weltzer, M. T., Reynolds, L. J., Rashid, C. S., Swanson, H. I., & Pearson, K. J. (2023). Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance. Frontiers in Endocrinology, 14, 1-9, Article 1085958. https://doi.org/10.3389/fendo.2023.1085958

ORCID

0000-0003-0075-2168 (Reynolds)

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