A selection of publications from researchers in the Frank Reidy Center for Bioelectrics at Old Dominion University.

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Submissions from 2015

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Histone Deacetylase Inhibitors Prevent Pulmonary Endothelial Hyperpermeability and Acute Lung Injury By Regulating Heat Shock Protein 90 Function, Atul D. Joshi, Nektarios Barabutis, Charalampos Birmpas, Christiana Dimitropoulou, Gagan Thangjam, Mary Cherian-Shaw, John Dennison, and John D. Catravas

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Introduction to Fifth Special Issue on Electroporation-Based Technologies and Treatments, Damijan Miklavčič, Lluis M. Mir, and P. Thomas Vernier

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Simulation Study of HEMT Structures With HfO2 Cap Layer For Mitigating Inverse Piezoelectric Effect Related Device Failures, Deepthi Nagulapally, Ravi P. Joshi, and Aswini Pradhan

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Differential Dielectric Responses of Chondrocyte and Jurkat Cells in Electromanipulation Buffers, Ahmet C. Sabuncu, Anthony J. Asmar, Michael W. Stacey, and Ali Beskok

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Cell Stimulation and Calcium Mobilization by Picosecond Electric Pulses, Iurii Semenov, Shu Xiao, Dongkoo Kang, Karl H. Schoenbach, and Andrei G. Pakhomov

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Diffuse, Non-Polar Electropermeabilization and Reduced Propidium Uptake Distinguish the Effect of Nanosecond Electric Pulses, Iurii Semenov, Christian Zemlin, Olga N. Pakhomova, Shu Xiao, and Andrei G. Pakhomov

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Picosecond to Terahertz Perturbation of Interfacial Water and Electropermeabilization of Biological Membranes, P. Thomas Vernier, Zachary A. Levine, Ming-Chak Ho, Shu Xiao, Iurii Semenov, and Andrei G. Pakhomov

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Ablation of Myocardial Tissue With Nanosecond Pulsed Electric Fields, Fei Xie, Frency Varghese, Andrei G. Pakhomov, Iurii Semenov, Shu Xiao, Jonathan Philpott, and Christian Zemlin

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In Situ OH Generation From O2- and H2O2 Plays a Critical Role in Plasma Induced Cell Death, Dehui Xu, Dingxing Liu, Biqing Wang, Chen Chen, Zeyu Chen, Dong Li, Yanjie Yang, Hailan Chen, and Michael G. Kong

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Refraction of Scroll-Wave Filaments at the Boundary between Two Reaction-Diffusion Media, Christian W. Zemlin, Frency Varghese, Marcel Wellner, and Arkady M. Pertsov

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Microbubble Generation by Piezotransducer for Biological Studies, W. Zhu, M. Alkhazal, M. Cho, and S. Xiao

Submissions from 2014

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Dimethylarginine Dimethylaminohydrolase II Overexpression Attenuates LPS-Mediated Lung Leak in Acute Lung Injury, Saurabh Aggarwal, Christine M. Gross, Sanjiv Kumar, Christiana Dimitropoulou, Shruti Sharma, Boris A. Gorshkov, Supriya Sridhar, Qing Lu, Natalia V. Bogatcheva, Agnieszka J. Jezierska-Drutel, Rudolf Lucas, John D. Catravas, and Stephen M. Black

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Concepts of Cancer and a Novel Cancer Therapy: Treating Tumors as an Aggressive Organ, Stephen J. Beebe

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PKC-Dependent Phosphorylation of eNOS at T495 Regulates eNOS Coupling and Endothelial Barrier Function in Response to G(+) -Toxins, Feng Chen, Sanjiv Kumar, Yanfang Yu, Saurabh Aggarwal, Christine Gross, Yusi Wang, Trinad Chakraborty, Alexander D. Verin, John D. Catravas, Rudolf Lucas, Stephen M. Black, and David J. R. Fulton

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Gene Electrotransfer Enhanced by Nanosecond Pulsed Electric Fields, Sigi Guo, Diane L. Jackson, Niculina I. Burcus, Yeong-Jer Chen, Shu Xiao, and Richard Heller

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Autologous Platelet Rich Plasma (Platelet Gel): An Appropriate Intervention for Salvaging Cardiac Myocytes Under Oxidative Stress After Myocardial Infarction, Barbara Y. Hargrave

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Gene Electro Transfer of Plasmid Encoding Vascular Endothelial Growth Factor for Enhanced Expression and Perfusion in the Ischemic Swine Heart, Barbara Y. Hargrave, Robert Strange Jr., Sagar Navare, Michael Stratton, Nina Burcus, Len Murray, Cathryn Lundberg, Anna Bulysheva, Fanying Li, and Richard Heller

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Bipolar Nanosecond Electric Pulses are Less Efficient at Electropermeabilization and Killing Cells than Monopolar Pulses, Bennett L. Ibey, Olga N. Pakhomova, Caleb C. Roth, Shu Xiao, Karl Schoenbach, and Andrei G. Pakhomov

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Heat Shock Protein 90 Inhibitors Prevent LPS-Induced Endothelial Barrier Dysfunction by Disrupting Rhoa Signaling, Atul D. Joshi, Christiana Dimitropoulou, Gagan S. Thangjam, Connie Snead, Sara Feldman, Nektarios Barabutis, David Fulton, Yali Hou, Sanjiv Kumar, Vijay Patel, Boris Gorshkov, Alexander D. Verin, Stephen M. Black, and John D. Catravas

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Electrochemotherapy: From the Drawing Board into Medical Practice, Damijan Miklavčič, Barbara Mali, Bor Kos, Richard Heller, and Gregor Serša

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Introduction to Fourth Special Issue on Electroporation-Based Technologies and Treatments, Damijan Miklavčič, Lluis M. Mir, and P. Thomas Vernier

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Cancellation of Cellular Responses to Nanoelectroporation by Reversing the Stimulus Polarity, Andrei G. Pakhomov, Iurii Semenov, Shu Xiao, Olga N. Pakhomova, Betsy Gregory, and Karl H. Schoenbach

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Disassembly of Actin Structures by Nanosecond Pulsed Electric Field is a Downstream Effect of Cell Swelling, Andrei G. Pakhomov, Shu Xiao, Olga N. Pakhomova, Iurii Semenov, Marjorie A. Kuipers, and Bennett L. Ibey

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Calcium-Mediated Pore Expansion and Cell Death Following Nanoelectroporation, Olga N. Pakhomova, Betsy Gregory, Iurii Semenov, and Andrei G. Pakhomov

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Cellular Regulation of Extension and Retraction of Pseudopod-Like Blebs Produced by Nanosecond Pulsed Electric Field, Mikhail A. Rassokhin and Andrei G. Pakhomov

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Basic Features of a Cell Electroporation Model: Illustrative Behavior for Two Very Different Pulses, Reuben S. Son, Kyle C. Smith, Thiruvallur R. Gowrishankar, P. Thomas Vernier, and James C. Weaver

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Numerical Study of Lipid Translocation Driven by Nanoporation Due to Multiple High-Intensity, Ultrashort Electrical Pulses, Viswanadham Sridhara and Ravindra P. Joshi

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Evaluations of a Mechanistic Hypothesis for the Influence of Extracellular Ions on Electroporation Due to High-Intensity, Nanosecond Pulsing, V. Sridhara and R. P. Joshi

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Dielectric Characterization of Coastal Cartilage Chondrocytes, Michael W. Stacey, Ahmet C. Sabuncu, and Ali Beskok

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Novel Mechanism of Attenuation of LPS-Induced NF-Kappab Activation by the Heat Shock Protein 90 Inhibitor, 17-N-Allylamino-17-Demethoxygeldanamycin, in Human Lung Microvascular Endothelial Cells, Gagan S. Thangjam, Christiana Dimitropoulou, Atul D. Joshi, Nektarios Barabutis, Mary C. Shaw, Yevgeniy Kovalenkov, Christopher M. Wallace, David J. Fulton, Vijay Patel, and John D. Catravas

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Enhanced Breast Cancer Therapy with nsPEFs and Low Concentrations of Gemcitabine, Shan Wu, Jinsong Guo, Wendong Wei, Jue Zhang, Jing Fang, and Stephen J. Beebe

Submissions from 2013

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Applications for Pulse Power using Nanosecond Pulsed Electric Fields (nsPEFs) in Cell Biology and Cancer Treatment, Stephen J. Beebe

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Bioelectrics in Basic Science and Medicine: Impact of Electric Fields on Cellular Structures and Functions, Stephen J. Beebe

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Cell Responses Without Receptors and Ligands, Using Nanosecond Pulsed Electric Fields (nsPEFs), Stephen J. Beebe

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Induction of Cell Death Mechanisms and Apoptosis by Nanosecond Pulsed Electric Fields (nsPEFs), Stephen J. Beebe, Nova M. Sain, and Wei Ren

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Nanosecond Pulsed Electric Field (nsPEF) Ablation as an Alternative or Adjunct to Surgery for Treatment of Cancer, Ru Chen, Xinhua Chen, and Stephen J. Beebe

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CpG and Interleukin-15 Synergize to Enhance IFN-gamma Production by Activated CD8(+) T Cells, Dustin Cobb, Sigi Guo, and Ronald B. Smeltz

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Functional Effects of KCNQ K(+) Channels in Airway Smooth Muscle, Alexey I. Evseev, Iurii Semenov, Crystal R. Archer, Jorge L. Medina, Peter H. Dube, Mark S. Shapiro, and Robert Brenner

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Topical Gene Electrotransfer to the Epidermis of Hairless Guinea Pig by Non-invasive Multielectrode Array, Sigi Guo, Annelise L. Israel, Gaurav Basu, Amy Donate, and Richard Heller

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Electroporation-Mediated Gene Transfer Directly to the Swine Heart, Barbara Hargrave, Harre Downey, Cathryn Lundberg, Annelise Israel, Yeong-Jer Chen, and Richard Heller

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Electrotransfer of Single-Stranded or Double-Stranded DNA Induces Complete Regression of Palpable B16.F10 Mouse Melanomas, Loree Heller, Vesba Todorovic, and Maja Cemazar

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Molecular Dynamics Simulations of Ion Conductance in Field-Stabilized Nanoscale Lipid Electropores, Ming-Chak Ho, Maura Casciola, Zachary A. Levine, and P. Thomas Vernier

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Special Issue on Plenary and Invited Papers From ICOPS 2012, Felipe Iza, Carl Ekdahl, and Michael G. Kong

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Fine Tuning a Well-Oiled Machine: Influence of NK1.1 and NKG2D on NKT Cell Development and Function, Sunil K. Joshi and Mark L. Lang

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Response to "Sodium Current Inhibition by Nanosecond Pulsed Electric Field (nsPEF) - Fact or Artifact?" by Verkerk et al, Andrei G. Pakhomov

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Facilitation of Electroporative Drug Uptake and Cell Killing by Electrosensitization, Olga N. Pakhomova, Betsy W. Gregory, and Andrei G. Pakhomov

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Two Modes of Cell Death Caused by Exposure to Nanosecond Pulsed Electric Field, Olga N. Pakhomova, Betsy W. Gregory, Iurii Semenov, and Andrei G. Pakhomov

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Primary Pathways of Intracellular Ca2+ Mobilization by Nanosecond Pulsed Electric Field, Iurii Semenov, Shu Xiao, and Andrei G. Pakhomov

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Recruitment of the Intracellular Ca2+ By Ultrashort Electric Stimuli: The Impact of Pulse Duration, Iurii Semenov, Shu Xiao, Olga N. Pakhomova, and Andrei G. Pakhomov

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Atomic Force Microscopy Characterization of Collagen ‘Nanostraws’ in Human Costal Cartilage, Michael W. Stacey, Diganta Dutta, Anthony Asmar, H. Elsayed-Ali, R. Kelly Jr., and A. Beskok

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Electric Field-Driven Water Dipoles: Nanoscale Architecture of Electroporation, Mayya Tokman, Jane HyoJin Lee, Zachary A. Levine, Ming-Chak Ho, Michael E. Colvin, and P. Thomas Vernier

Submissions from 2012

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Enhanced Killing Effect of Nanosecond Pulse Electric Fields on PANC1 and Jurkat Cell Lines in the Presence of Tween 80, Gaurav Basu, Bhargava Subhash Kalluri, Ahmet Can Sabuncu, Christopher J. Osgood, and Michael W. Stacey

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Transient Features in Nanosecond Pulsed Electric Fields Differentially Modulate Mitochondria and Viability, Stephen J. Beebe, Yeong-Jer Chen, Nova M. Sain, Karl H. Schoenbach, and Shu Xiao

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Long Term Survival of Mice With Hepatocellular Carcinoma after Pulse Power Ablation with Nanosecond Pulsed Electric Fields, X. Chen, J. Zhuang, J. F. Kolb, Karl H. Schoenbach, and Stephen J. Beebe

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An Extracellular Domain of the Accessory Beta1 Subunit Is Required for Modulating BK Channel Voltage Sensor and Gate, Aleksandra Gruslova, Iurii Semenov, and Bin Wang

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Inactivation of Bacterial Opportunistic Skin Pathogens by Nonthermal DC-Operated Afterglow Atmospheric Plasma, L. C. Heller, C. M. Edelblute, A. M. Mattson, X. Hao, and J. F. Kolb

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Advancing Our Understanding of the Inheritance and Transmission of Pectus Excavatum, Lisa Horth, Michael W. Stacey, Virginia K. Proud, Kara Segna, Chelsea Rutherford, Donald Nuss, and Robert E. Kelly

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In Vitro Antimicrobial Effect of a Cold Plasma Jet against Enterococcus faecalis Biofilms, Chunqi Jiang, Christoph Schaudinn, David E. Jaramillo, Paul Webster, and J. William Costerton

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Subcellular Biological Effects of Nanosecond Pulsed Electric Fields, Juergen F. Kolb and Michael W. Stacey

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The Use of an in vitro 3D Melanoma Model to Predict in vivo Plasmid Transfection Using Electroporation, Benadette Marrero and Richard Heller

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Cell Permeabilization and Inhibition of Voltage-Gated Ca²+ and Na+ Channel Currents by Nanosecond Pulsed Electric Fields, Vasyl Nesin, Angela M. Bowman, Shu Xiao, and Andrei G. Pakhomov

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Inhibition of Voltage-Gated Na+ Current by Nanosecond Pulsed Electric Field (nsPEF) is Not Mediated by NA+ Influx or Ca²+ Signaling, Vasyl Nesin and Andrei G. Pakhomov

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Oxidative Effects of Nanosecond Pulsed Electric Field Exposure in Cells and Cell-Free Media, Olga N. Pakhomova, Vera A. Khorokhorina, Angela M. Bowman, Raminta Rodaitė-Riševičienė, Gintautas Saulis, Shu Xiao, and Andrei G. Pakhomov

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Electric Field Exposure Triggers and Guides Formation of Pseudopod-Like Blebs in U937 Monocytes, Mikhail A. Rassokhin and Andrei G. Pakhomov

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Probing Nanoparticle Interactions in Cell Culture Media, Ahmet C. Sabuncu, Janna Grubbs, Shizhi Qian, Tarek M. Abdel-Fattah, Michael W. Stacey, and Ali Beskok

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In vitro Measurements of Tracheal Constriction Using Mice, Iurii Semenov, Jeremiah T. Herlihy, and Robert Brenner

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Decorin Expression, Straw-Like Structure, and Differentiation of Human Costal Cartilage, Michael W. Stacey, Janna Grubb, Anthony Asmar, Julie Pryor, Hani Elsayed-Ali, Ali Beskok, Diganta Dutta, Annie Fecteau, Alice Werner, Dennis A. Darby, and Robert Kelly

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Synergistic Effects of Nanosecond Pulsed Electric Fields Combined with Low Concentration of Gemcitabine on Human Oral Squamous Cell Carcinoma In Vitro, Jing Wang, Jinsong Guo, Shan Wu, Hongqing Feng, Shujun Sun, Jie Pan, Jue Zhang, and Stephen J. Beebe

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Cutaneous Papilloma and Squamous Cell Carcinoma Therapy Utilizing Nanosecond Pulsed Electric Fields (nsPEF), Dong Yin, Wangrong G. Yang, Jack Weissberg, Catherine B. Goff, Weikai Chen, Yoshio Kuwayama, Amanda Leiter, Hongtao Xing, Antonie Meixel, Daria Gaut, Fikret Kirkbir, David Sawcer, P. Thomas Vernier, Jonathan W. Said, Martin A. Gundersen, and H. Phillip Koeffler

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Anchoring of Drifting Spiral and Scroll Waves to Impermeable Inclusions in Excitable Media, Christian W. Zemlin and Arkady M. Pertsov

Submissions from 2011

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Comparative Study of Long-and Short-Pulsed Electric Fields for Treating Melanoma in an In Vivo Mouse Model, Xinhua Chen, Xinmei Chen, Karl H. Schoenbach, Shusen Zheng, and R. James Swanson

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Limited Transplantation of Antigen-Expressing Hematopoietic Stem Cells Induces Long-Lasting Cytotoxic T Cell Responses, Warren L. Denning, Jun Xu, Siqi Guo, Christopher A. Klug, and Zdenek Hel

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Evaluation of a Novel Non-Penetrating Electrode for Use in DNA Vaccination, Amy Donate, Domenico Coppola, Yolmari Cruz, and Richard Heller

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Evaluation of Delivery Conditions for Cutaneous Plasmid Electrotransfer Using a Multielectrode Array, Bernadette Ferraro, Loree C. Heller, Yolmari L. Cruz, Siqi Guo, Amy Donate, and Richard Heller

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Exploring Tissue Response to Field Mediated Plasmid Delivery, Richard Gilbert, J. Anthony Llewellyn, Karl H. Schoenbach, Loree C. Heller, and Andrew Hoff

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Electro-Gene Transfer to Skin Using a Noninvasive Multielectrode Array, Siqi Guo, Amy Donate, Gaurav Basu, Cathryn Lundberg, Loree Heller, and Richard Heller

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Dose-Dependent Thresholds of 10-ns Electric Pulse Induced Plasma Membrane Disruption and Cytotoxicity in Multiple Cell Lines, Bennett L. Ibey, Caleb C. Roth, Andrei G. Pakhomov, Joshua A. Bernhard, Gerald J. Wilmink, and Olga N. Pakhomova

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A Novel Pulsed Corona Discharge Reactor Based on Surface Streamers for NO Conversion from N2-O2 Mixture Gases, M. A. Malik and Karl H. Schoenbach

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Electroporation-Induced Electrosensitization, Olga N. Pakhomova, Betsy W. Gregory, Vera A. Khorokhorina, Anglela M. Bowman, Shu Xiao, and Andrei G. Pakhomov

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An Apoptosis Targeted Stimulus with Nanosecond Pulsed Electric Fields (nsPEFs) in E4 squamous Cell Carcinoma, Wei Ren and Stephen J. Beebe

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DNA Electrophoretic Migration Patterns Change after Exposure of Jurkat Cells to a Single Intense Nanosecond Electric Pulse, Stefania Romeo, Luigi Zeni, Maurizio Sarti, Anna Sannino, Maria Rosaria Scarfi, P. Thomas Vernier, and Olga Zeni

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Nanosecond Pulsed Electric Field Induced Cytoskeleton, Nuclear Membrane and Telomere Damage Adversely Impact Cell Survival, Michael W. Stacey, P. Fox, S. Buescher, and Juergen F. Kolb

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Nanosecond Pulse Electrical Fields Used in Conjunction with Multi-Wall Carbon Nanotubes as a Potential Tumor Treatment, Michael W. Stacey, Christopher Osgood, Bhargava Subhash Kalluri, Wei Cao, Hani Elsayed-Ali, and Tarek Abdel-Fattah

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Targeted Identification of Metastasis-Associated Cell-Surface Sialoglycoproteins in Prostate Cancer, Lifang Yang, Julius O. Nyalwidhe, Sigi Guo, Richard R. Drake, and O. John Semmes

Submissions from 2010

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Bioelectric Applications for Treatment of Melanoma, Stephen J. Beebe, Karl H. Schoenbach, and Richard Heller

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Apoptosis Initiation and Angiogenesis Inhibition: Melanoma Targets for Nanosecond Pulsed Electric Fields, Xinhua Chen, Juergen F. Kolb, R. James Swanson, Karl H. Schoenbach, and Stephen J. Beebe

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CD1d-Dependent B-Cell Help by NK-Like T Cells Leads to Enhanced and Sustained Production of Bacillus Anthracis Lethal Toxin-Neutralizing Antibodies, T. Scott Devera, Lindsay M. Aye, Gillian A. Lang, Sunil K. Joshi, Jimmy D. Ballard, and Mark L. Lang

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Increased Perfusion and Angiogenesis in a Hindlimb Ischemia Model with Plasmid FGF-2 Delivered by Noninvasive Electroporation, B. Ferraro, Y. L. Cruz, M. Baldwin, D. Coppola, and R. Heller

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Plasmid Injection and Application of Electric Pulses Alter Endogenous mRNA and Protein Expression in B16.F10 Mouse Melanomas, L. C. Heller, Y. L. Cruz, B. Ferraro, H. Yang, and R. Heller

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Electrically Mediated Delivery of Plasmid DNA to the Skin, Using a Multielectrode Array, Richard Heller, Yolmari Criz, Loree C. Heller, Richard A. Gilbert, and Mark J. Jaroszeski

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Electroporation-Mediated Delivery of a Naked DNA Plasmid Expressing VEGF to the Porcine Heart Enhances Protein Expression, W. G. Marshall Jr., B. A. Boone, J. D. Burgos, S. I. Gografe, M. K. Baldwin, M. L. Danielson, M. J. Larson, D. R. Caretto, Y. Cruz, B. Ferraro, L. C. Heller, K. E. Ugen, M. J. Jaroszeski, and R. Heller

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Crystallization of Community-Acquired Respiratory Distress Syndrome Toxin from Mycoplasma Pneumonia, Olga N. Pakhomova, Alexander B. Taylor, Argentina Becker, Stephen P. Holloway, T. R. Kannan, Joel B. Baseman, and P. John Hart

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Dielectrophoretic Separation of Mouse Melanoma Clones, Ahmet C. Sabuncu, Jie A. Liu, Stephen J. Beebe, and Ali Beskok

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Variable Number of Tandem Repeat Polymorphisms (VNTRs) in the ACAN Gene Associated with Pectus Excavatum, Michael W. Stacey, Serina Neumann, Ashley Dooley, Kara Segna, Robert Kelly, Donald Nuss, Anne Kuhn, Michael Goretsky, Annie Fecteau, Aimee Pastor, and Virginia Proud

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3,4-Methylenedioxymethamphetamine Alters Left Ventricular Function and Activates Nuclear Factor-Kappa B (NF-kappaB) in a Time and Dose Dependent Manner, David A. Tiangco, Sapna Halcomb, Frank A. Lattanzio Jr, and Barbara Y. Hargrave

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Frustrated Drift of an Anchored Scroll-Wave Filament and the Geodesic Principle, Marcel Wellner, Christian W. Zemlin, and Arkady M. Pertsov

Submissions from 2009

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Electroporation for the Delivery of DNA-Based Vaccines and Immunotherapeutics: Current Clinical Developments, Angela M. Bodles-Brakhop, Richard Heller, and Ruxandra Draghia-Akli

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Intradermal Delivery of Plasmid VEGF(165) by Electroporation Promotes Wound Healing, Bernadette Ferraro, Yolmari Cruz, Domenico Coppola, and Richard Heller

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A New Pulsed Electric Field Therapy for Melanoma Disrupts the Tumor's Blood Supply and Causes Complete Remission Without Recurrence, Richard Nuccitelli, Xinhua Chen, Andrei G. Pakhomov, Wallace H. Baldwin, Saleh Sheikh, Jennifer L. Pomicter, Wei Ren, Chris Osgood, R. James Swanson, Juergen F. Kolb, Stephen J. Beebe, and Karl H. Schoenbach

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Regulation of Intracellular Calcium Concentration by Nanosecond Pulsed Electric Fields, Shaka S. Scarlett, Jody A. White, Peter F. Blackmore, Karl H. Schoenbach, and Juergen Kolb