A selection of publications from researchers in the Frank Reidy Center for Bioelectrics at Old Dominion University.

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Submissions from 2016

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Membrane Channel Gene Expression in Human Costal and Articular Chondrocytes, A. Asmar, R. Barrett-Jolley, A. Werner, R. Kelly Jr., and M. Stacey

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Radio-Frequency Plasma Polymerized Biodegradable Carrier for in vivo Release of Cis-Platinum, Sudhir Bhatt, Fatemeh Valamanesh, Jerome Pulpytel, Rea Lo Dico, Aliby Baiyukha, Iman Al-dybiat, Marc Pocard, Farzaneh Arefi-Khonsari, and Massoud Mirshahi

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Vascular Endothelial Growth Factor-A Gene Electrotransfer Promotes Angiogenesis in a Porcine Model of Cardiac Ischemia, Anna A. Bulysheva, Barbara Hargrave, Nina Burcus, Cathryn G. Lundberg, Len Murray, and Richard Heller

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Cloning, Characteristics, and Functional Analysis of Rabbit NADPH Oxidase 5, Feng Chen, Caiyong Yin, Christiana Dimitropoulou, and David J.R. Fulton

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Cell Electrosensitization Exists Only in Certain Electroporation Buffers, Janja Dermol, Olga N. Pakhomova, Andrei G. Pakhomov, and Damijan Miklavčič

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Thermal Assisted In Vivo Gene Electrotransfer, Amy Donate, Anna Bulysheva, Chelsea Edelblute, Derrick Jung, A. Malik, Siqi Quo, Niculina Burcus, Karl Schoenbach, and Richard Heller

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Plasma-Activated Air Mediates Plasmid DNA Delivery In Vivo, Chelsea M. Edelblute, Loree C. Heller, Muhammad A. Malik, Anna Bulysheva, and Richard Heller

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Nanosecond Pulsed Platelet-Rich Plasma (nsPRP) Improves Mechanical and Electrial Cardiac Function Following Myocardial Reperfusion Injury, Barbara Y. Hargrave, Frency Varghese, Nektarios Barabutis, John Catravas, and Christian Zemlin

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Inactivation of Acanthamoeba spp. and Other Ocular Pathogens By Application of Cold Atmospheric Gas Plasma, Wayne Heaselgrave, Gilbert Shama, Peter W. Andrew, and Michael G. Kong

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Activation of DNA Pattern Recognition Receptors After Plasmid Electrotransfer in Melanoma Cells and Tumors, Loree Heller, Masa Bosnjak, Katarina Znidar, and Maja Cemazar

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A 'Tissue Model' to Study the Barrier Effects of Living Tissues on the Reactive Species Generated by Surface Air Discharge, Tongtong He, Dingxin Liu, Han Xu, Zhichao Liu, Dehui Xu, Dong Li, Qiosong Li, Mingzhe Rong, and Michael G. Kong

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The Protective Role of MLCP-Mediated ERM Dephosphorylation in Endotoxin-Induced Lung Injury in Vitro and in Vivo, Anita Kovacs-Kasa, Boris A. Gorshkov, Kyung-Mi Kim, Sanjiv Kumar, Stephen M. Black, David J. Fulton, Christiana Dimitropoulou, John D. Catravas, and Alexander D. Verin

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Comparison Between Electropositive and Electronegative Cold Atmospheric-Pressure Plasmas: A Modelling Study, Ding X. Liu, Jia F. Li, Ai J. Yang, Xiao H. Wang, Ming Z. Rong, and Michael G. Kong

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Aqueous Reactive Species Induced by a Surface Air Discharge: Heterogenous Mass Transfer and Liquid Chemistry Pathways, D. X. Liu, Z. C. Liu, C. Chen, A. J. Yang, D. Li, M. Z. Rong, H. L. Chen, and M. G. Kong

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Hydrocortisone, Vitamin C and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study, Paul E. Marik, Vikramjit Khangoora, Racquel Rivera, Michael H. Hooper, and John Catravas

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The Cytotoxic Synergy of Nanosecond Electric Pulses and Low Temperature Leads to Apoptosis, Claudia Muratori, Andrei G. Pakhomov, Elena C. Gianulis, Sarah D. Jensen, and Olga N. Pakhomova

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Electrosensitization Assists Cell Ablation by Nanosecond Pulsed Electric Field in 3D Cultures, Claudia Muratori, Andrei G. Pakhomov, Shu Xiao, and Olga N. Pakhomova

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Effects of High Voltage Nanosecond Electric Pulses on Eukaryotic Cells (in vitro): A Systematic Review, Tina Batista Napotink, Matej Reberšek, P. Thomas Vernier, Babara Mali, and Damijan Miklavčič

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A Dielectric Rod Antenna for Picosecond Pulse Stimulation of Neurological Tissue, Ross A. Petrella, Karl H. Schoenbach, and Shu Xiao

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A Novel Copper (II) Complex Identified as a Potent Drug Against Colorectal and Breast Cancer Cells and as a Poison Inhibitor for Human Topoisomerase IIᶐ, Shayna Sandhaus, Rosella Taylor, Tiffany Edwards, Alexis Huddleston, Stephen J. Beebe, and Alvin A. Holder

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20 Years of Microplasma Research: A Status Report, Karl H. Schoenbach and Kurt Becker

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Electroporation by Subnanosecond Pulses, Iurii Semenov, Shu Xiao, and Andrei G. Pakhomov

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Zika Virus- Emergence, Evolution, Pathology, Diagnosis, and Control: Current Global Scenario and Future Perspectives- A Comprehensive Review, Raj K. Singh, Kuldeep Dhama, Yashpal S. Malik, Muthannan A. Ramakrishnan, Kumaragurubaran Karthik, and Sunil K. Joshi

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Hsp90 Inhibition Suppresses NF-κB Transcriptional Activation via Sirt-2 in Human Lung Microvascular Endothelial Cells, Gagan S. Thangjam, Charalampos Birmpas, Nektarios Barabutis, Betsy W. Gregory, Mary Ann Clemens, Joseph R. Newton, David Fulton, and John D. Catravas

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Experimental Assessment of Mouse Sociability Using an Automated Image Processing Approach, Frency Varghese, Jessica A. Burket, Andrew D. Benson, Stephen I. Deutsch, and Christian W. Zemlin

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Effect of Twisted Fiber Anisotropy in Cardiac Tissue on Ablation with Pulsed Electric Fields, Fei Xie and Christian W. Zemlin

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Intracellular ROS Mediates Gas Plasma-Facilitated Cellular Transfection in 2D and 3D Cultures, Dehui Xu, Biqing Wang, Yujing Xu, Zeyu Chen, Qinjie Cui, Yanjie Yang, Hailan Chen, and Michael G. Kong

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Cytosolic DNA Sensor Upregulation Accompanies DNA Electrotransfer in B16.F10 Melanoma Cells, Katarina Znidar, Masa Bosnjak, Maja Cemazar, and Loree C. Heller

Submissions from 2015

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Presence and Localization of Pro-and Mature Forms of Biglycan and Decorin in Human Costal Cartilage Derived from Chest Wall Deformities, Anthony Asmar, A. Werner, R. E. Kelly Jr., A. Fecteau, and Michael W. Stacey

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P53: "The Wall Watcher", Nektarios Barabutis and John D. Catravas

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Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating Cytotoxin from Mycoplasma Pneumoniae, Argentina Becker, T. R. Kannan, Alexander B. Taylor, Olga N. Pakhomova, Yanfeng Zhang, Sudha R. Somarajan, Ahmad Galaleldeen, Stephen P. Holloway, Joel B. Baseman, and P. John Hart

Hepatocellular Carcinoma Ablation and Possible Immunity in the Age of Nanosecond Pulsed Electric Fields, Stephen J. Beebe

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Mechanisms of Nanosecond Pulsed Electric Field (NsPEF)-Induced Cell Death in Cells and Tumors, Stephen J. Beebe

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Increased Tissue Temperature Improves Electro-Transfer Mediated Gene Delivery to Skin, Anna Bulysheva, Amy Donate, Chelsea Edelblute, Derrick Jung, Karl Schoenbach, and Richard Heller

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Long-Term Overall Survival From a Phase 1 Trial Using Intratumoral Plasmid Interleukin-12 With Electroporation in Patients with Melanoma, Adil Daud, Kathryn T. Takamura, Tu Diep, Richard Heller, and Robert H. Pierce

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Immunization of Mice with Anthrax Protective Antigen Limits Cardiotoxicity but Not Hepatotoxicity Following Lethal Toxin Challenge, T. Scott Devera, Dawn K. Prusator, Sunil K. Joshi, Jimmy D. Ballard, and Mark L. Lang

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Effects of Nanosecond Pulse Electric Fields on Cellular Elasticity, Diganta Dutta, Anthony Asmar, and Michael W. Stacey

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Human Platelet Gel Supernatant Inactivates Opportunistic Wound Pathogens on Skin, Chelsea M. Edelblute, Amy L. Donate, Barbara Y. Hargrave, and Loree C. Heller

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Donor Platelet Plasma Components Inactivate Sensitive and Multidrug Resistant Acinetobacter Baumannii Isolates, Chelsea M. Edelblute, Olga N. Pakhomova, Fanying Li, Barbara Y. Hargrave, and Loree C. Heller

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Electroporation of Mammalian Cells by Nanosecond Electric Field Oscillations and it's Inhibition by the Electric Field Reversal, Elena C. Gianulis, Jimo Lee, Chunqi Jiang, Shu Xiao, Bennet L. Ibey, and Andrei G. Pakhomov

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Gadolinium Modifies the Cell Membrane to Inhibit Permeabilization by Nanosecond Electric Pulses, Elena C. Gianulis and Andrei G. Pakhomov

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Dose-Dependent ATP Depletion and Cancer Cell Death following Calcium Electroporation, Relative Effect of Calcium Concentration and Electric Field Strength, Emilie Louise Hansen, Esin Bengisu Sozer, Stefania Romeo, Stine Krog Frandsen, P. Thomas Vernier, and Julie Gehl

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Nanosecond Pulse Electric Field Activated-Platelet Rich Plasma Enhances the Return of Blood Flow to Large and Ischemic Wounds in a Rabbit Model, Barbara Y. Hargrave and Francis Li

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Histone Deacetylase Inhibitors Prevent Pulmonary Endothelial Hyperpermeability and Acute Lung Injury By Regulating Heat Shock Protein 90 Function, Atul D. Joshi, Nektarios Barabutis, Charalampos Birmpas, Christiana Dimitropoulou, Gagan Thangjam, Mary Cherian-Shaw, John Dennison, and John D. Catravas

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Introduction to Fifth Special Issue on Electroporation-Based Technologies and Treatments, Damijan Miklavčič, Lluis M. Mir, and P. Thomas Vernier

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Simulation Study of HEMT Structures With HfO2 Cap Layer For Mitigating Inverse Piezoelectric Effect Related Device Failures, Deepthi Nagulapally, Ravi P. Joshi, and Aswini Pradhan

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Differential Dielectric Responses of Chondrocyte and Jurkat Cells in Electromanipulation Buffers, Ahmet C. Sabuncu, Anthony J. Asmar, Michael W. Stacey, and Ali Beskok

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Cell Stimulation and Calcium Mobilization by Picosecond Electric Pulses, Iurii Semenov, Shu Xiao, Dongkoo Kang, Karl H. Schoenbach, and Andrei G. Pakhomov

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Diffuse, Non-Polar Electropermeabilization and Reduced Propidium Uptake Distinguish the Effect of Nanosecond Electric Pulses, Iurii Semenov, Christian Zemlin, Olga N. Pakhomova, Shu Xiao, and Andrei G. Pakhomov

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Picosecond to Terahertz Perturbation of Interfacial Water and Electropermeabilization of Biological Membranes, P. Thomas Vernier, Zachary A. Levine, Ming-Chak Ho, Shu Xiao, Iurii Semenov, and Andrei G. Pakhomov

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Ablation of Myocardial Tissue With Nanosecond Pulsed Electric Fields, Fei Xie, Frency Varghese, Andrei G. Pakhomov, Iurii Semenov, Shu Xiao, Jonathan Philpott, and Christian Zemlin

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In Situ OH Generation From O2- and H2O2 Plays a Critical Role in Plasma Induced Cell Death, Dehui Xu, Dingxing Liu, Biqing Wang, Chen Chen, Zeyu Chen, Dong Li, Yanjie Yang, Hailan Chen, and Michael G. Kong

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Refraction of Scroll-Wave Filaments at the Boundary between Two Reaction-Diffusion Media, Christian W. Zemlin, Frency Varghese, Marcel Wellner, and Arkady M. Pertsov

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Microbubble Generation by Piezotransducer for Biological Studies, W. Zhu, M. Alkhazal, M. Cho, and S. Xiao

Submissions from 2014

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Dimethylarginine Dimethylaminohydrolase II Overexpression Attenuates LPS-Mediated Lung Leak in Acute Lung Injury, Saurabh Aggarwal, Christine M. Gross, Sanjiv Kumar, Christiana Dimitropoulou, Shruti Sharma, Boris A. Gorshkov, Supriya Sridhar, Qing Lu, Natalia V. Bogatcheva, Agnieszka J. Jezierska-Drutel, Rudolf Lucas, John D. Catravas, and Stephen M. Black

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Concepts of Cancer and a Novel Cancer Therapy: Treating Tumors as an Aggressive Organ, Stephen J. Beebe

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PKC-Dependent Phosphorylation of eNOS at T495 Regulates eNOS Coupling and Endothelial Barrier Function in Response to G(+) -Toxins, Feng Chen, Sanjiv Kumar, Yanfang Yu, Saurabh Aggarwal, Christine Gross, Yusi Wang, Trinad Chakraborty, Alexander D. Verin, John D. Catravas, Rudolf Lucas, Stephen M. Black, and David J. R. Fulton

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Gene Electrotransfer Enhanced by Nanosecond Pulsed Electric Fields, Sigi Guo, Diane L. Jackson, Niculina I. Burcus, Yeong-Jer Chen, Shu Xiao, and Richard Heller

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Autologous Platelet Rich Plasma (Platelet Gel): An Appropriate Intervention for Salvaging Cardiac Myocytes Under Oxidative Stress After Myocardial Infarction, Barbara Y. Hargrave

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Gene Electro Transfer of Plasmid Encoding Vascular Endothelial Growth Factor for Enhanced Expression and Perfusion in the Ischemic Swine Heart, Barbara Y. Hargrave, Robert Strange Jr., Sagar Navare, Michael Stratton, Niculina Burcus, Len Murray, Cathryn Lundberg, Anna A. Bulysheva, Fanying Li, and Richard Heller

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Bipolar Nanosecond Electric Pulses are Less Efficient at Electropermeabilization and Killing Cells than Monopolar Pulses, Bennett L. Ibey, Olga N. Pakhomova, Caleb C. Roth, Shu Xiao, Karl Schoenbach, and Andrei G. Pakhomov

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Heat Shock Protein 90 Inhibitors Prevent LPS-Induced Endothelial Barrier Dysfunction by Disrupting Rhoa Signaling, Atul D. Joshi, Christiana Dimitropoulou, Gagan S. Thangjam, Connie Snead, Sara Feldman, Nektarios Barabutis, David Fulton, Yali Hou, Sanjiv Kumar, Vijay Patel, Boris Gorshkov, Alexander D. Verin, Stephen M. Black, and John D. Catravas

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Electrochemotherapy: From the Drawing Board into Medical Practice, Damijan Miklavčič, Barbara Mali, Bor Kos, Richard Heller, and Gregor Serša

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Introduction to Fourth Special Issue on Electroporation-Based Technologies and Treatments, Damijan Miklavčič, Lluis M. Mir, and P. Thomas Vernier

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Cancellation of Cellular Responses to Nanoelectroporation by Reversing the Stimulus Polarity, Andrei G. Pakhomov, Iurii Semenov, Shu Xiao, Olga N. Pakhomova, Betsy Gregory, and Karl H. Schoenbach

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Disassembly of Actin Structures by Nanosecond Pulsed Electric Field is a Downstream Effect of Cell Swelling, Andrei G. Pakhomov, Shu Xiao, Olga N. Pakhomova, Iurii Semenov, Marjorie A. Kuipers, and Bennett L. Ibey

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Calcium-Mediated Pore Expansion and Cell Death Following Nanoelectroporation, Olga N. Pakhomova, Betsy Gregory, Iurii Semenov, and Andrei G. Pakhomov

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Cellular Regulation of Extension and Retraction of Pseudopod-Like Blebs Produced by Nanosecond Pulsed Electric Field, Mikhail A. Rassokhin and Andrei G. Pakhomov

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Basic Features of a Cell Electroporation Model: Illustrative Behavior for Two Very Different Pulses, Reuben S. Son, Kyle C. Smith, Thiruvallur R. Gowrishankar, P. Thomas Vernier, and James C. Weaver

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Numerical Study of Lipid Translocation Driven by Nanoporation Due to Multiple High-Intensity, Ultrashort Electrical Pulses, Viswanadham Sridhara and Ravindra P. Joshi

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Evaluations of a Mechanistic Hypothesis for the Influence of Extracellular Ions on Electroporation Due to High-Intensity, Nanosecond Pulsing, V. Sridhara and R. P. Joshi

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Dielectric Characterization of Coastal Cartilage Chondrocytes, Michael W. Stacey, Ahmet C. Sabuncu, and Ali Beskok

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Novel Mechanism of Attenuation of LPS-Induced NF-Kappab Activation by the Heat Shock Protein 90 Inhibitor, 17-N-Allylamino-17-Demethoxygeldanamycin, in Human Lung Microvascular Endothelial Cells, Gagan S. Thangjam, Christiana Dimitropoulou, Atul D. Joshi, Nektarios Barabutis, Mary C. Shaw, Yevgeniy Kovalenkov, Christopher M. Wallace, David J. Fulton, Vijay Patel, and John D. Catravas

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Enhanced Breast Cancer Therapy with nsPEFs and Low Concentrations of Gemcitabine, Shan Wu, Jinsong Guo, Wendong Wei, Jue Zhang, Jing Fang, and Stephen J. Beebe

Submissions from 2013

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Applications for Pulse Power using Nanosecond Pulsed Electric Fields (nsPEFs) in Cell Biology and Cancer Treatment, Stephen J. Beebe

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Bioelectrics in Basic Science and Medicine: Impact of Electric Fields on Cellular Structures and Functions, Stephen J. Beebe

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Cell Responses Without Receptors and Ligands, Using Nanosecond Pulsed Electric Fields (nsPEFs), Stephen J. Beebe

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Induction of Cell Death Mechanisms and Apoptosis by Nanosecond Pulsed Electric Fields (nsPEFs), Stephen J. Beebe, Nova M. Sain, and Wei Ren

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Nanosecond Pulsed Electric Field (nsPEF) Ablation as an Alternative or Adjunct to Surgery for Treatment of Cancer, Ru Chen, Xinhua Chen, and Stephen J. Beebe

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CpG and Interleukin-15 Synergize to Enhance IFN-gamma Production by Activated CD8(+) T Cells, Dustin Cobb, Sigi Guo, and Ronald B. Smeltz

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Functional Effects of KCNQ K(+) Channels in Airway Smooth Muscle, Alexey I. Evseev, Iurii Semenov, Crystal R. Archer, Jorge L. Medina, Peter H. Dube, Mark S. Shapiro, and Robert Brenner

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Topical Gene Electrotransfer to the Epidermis of Hairless Guinea Pig by Non-invasive Multielectrode Array, Sigi Guo, Annelise L. Israel, Gaurav Basu, Amy Donate, and Richard Heller

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Electroporation-Mediated Gene Transfer Directly to the Swine Heart, Barbara Hargrave, Harre Downey, Cathryn Lundberg, Annelise Israel, Yeong-Jer Chen, and Richard Heller

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Electrotransfer of Single-Stranded or Double-Stranded DNA Induces Complete Regression of Palpable B16.F10 Mouse Melanomas, Loree Heller, Vesba Todorovic, and Maja Cemazar

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Molecular Dynamics Simulations of Ion Conductance in Field-Stabilized Nanoscale Lipid Electropores, Ming-Chak Ho, Maura Casciola, Zachary A. Levine, and P. Thomas Vernier

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Special Issue on Plenary and Invited Papers From ICOPS 2012, Felipe Iza, Carl Ekdahl, and Michael G. Kong

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Fine Tuning a Well-Oiled Machine: Influence of NK1.1 and NKG2D on NKT Cell Development and Function, Sunil K. Joshi and Mark L. Lang

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Response to "Sodium Current Inhibition by Nanosecond Pulsed Electric Field (nsPEF) - Fact or Artifact?" by Verkerk et al, Andrei G. Pakhomov

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Facilitation of Electroporative Drug Uptake and Cell Killing by Electrosensitization, Olga N. Pakhomova, Betsy W. Gregory, and Andrei G. Pakhomov

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Two Modes of Cell Death Caused by Exposure to Nanosecond Pulsed Electric Field, Olga N. Pakhomova, Betsy W. Gregory, Iurii Semenov, and Andrei G. Pakhomov

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Primary Pathways of Intracellular Ca2+ Mobilization by Nanosecond Pulsed Electric Field, Iurii Semenov, Shu Xiao, and Andrei G. Pakhomov

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Recruitment of the Intracellular Ca2+ By Ultrashort Electric Stimuli: The Impact of Pulse Duration, Iurii Semenov, Shu Xiao, Olga N. Pakhomova, and Andrei G. Pakhomov

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Atomic Force Microscopy Characterization of Collagen ‘Nanostraws’ in Human Costal Cartilage, Michael W. Stacey, Diganta Dutta, Anthony Asmar, H. Elsayed-Ali, R. Kelly Jr., and A. Beskok

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Electric Field-Driven Water Dipoles: Nanoscale Architecture of Electroporation, Mayya Tokman, Jane HyoJin Lee, Zachary A. Levine, Ming-Chak Ho, Michael E. Colvin, and P. Thomas Vernier

Submissions from 2012

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Enhanced Killing Effect of Nanosecond Pulse Electric Fields on PANC1 and Jurkat Cell Lines in the Presence of Tween 80, Gaurav Basu, Bhargava Subhash Kalluri, Ahmet Can Sabuncu, Christopher J. Osgood, and Michael W. Stacey

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Transient Features in Nanosecond Pulsed Electric Fields Differentially Modulate Mitochondria and Viability, Stephen J. Beebe, Yeong-Jer Chen, Nova M. Sain, Karl H. Schoenbach, and Shu Xiao

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Long Term Survival of Mice With Hepatocellular Carcinoma after Pulse Power Ablation with Nanosecond Pulsed Electric Fields, X. Chen, J. Zhuang, J. F. Kolb, Karl H. Schoenbach, and Stephen J. Beebe

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An Extracellular Domain of the Accessory Beta1 Subunit Is Required for Modulating BK Channel Voltage Sensor and Gate, Aleksandra Gruslova, Iurii Semenov, and Bin Wang

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Inactivation of Bacterial Opportunistic Skin Pathogens by Nonthermal DC-Operated Afterglow Atmospheric Plasma, L. C. Heller, C. M. Edelblute, A. M. Mattson, X. Hao, and J. F. Kolb

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Advancing Our Understanding of the Inheritance and Transmission of Pectus Excavatum, Lisa Horth, Michael W. Stacey, Virginia K. Proud, Kara Segna, Chelsea Rutherford, Donald Nuss, and Robert E. Kelly